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Process adaptation in fermentation based biomanufacturing
Chemistry and Biology
Organization logo: Technical University of Denmark

About this course

The main purpose of this course is to introduce students to the methods and tools that are used when transferring a cell from a lab or research environment to pilot and full scale. The student following this course should therefore acquire a better understanding of the interactions between the cells and the hardware (the reactor), and will learn how to aim for optimal conditions for the cells to grow in large scale. The lectures will be given by experienced DTU teachers, combined with guest teachers from industry. The course includes visits to the pilot plant of DTU Chemical Engineering and to industry (e.g. pilot plant environment).

Expected learning outcomes

  • At the end of the course the learner will be able to:

  • Set up a mass balance for different bioreactor operating modes

  • Simulate different reactor operating modes and interpret the simulation results

  • Describe the effect of introducing basic process control on a process in a bioreactor

  • Describe the essential challenges related to solid state fermentations and fermentation processes using gaseous substrates

  • Select a suitable set of on-line measurements for a cultivation process as well as distinguish between pros and cons of specific basic and advanced sensor devices

  • Describe the effect of scale on the performance of a microorganism as well as pros and cons of different methods to mathematically describe or simulate effects of scale

  • Develop process based strategies to optimize product formation in a fermentation process

  • Distinguish between different downstream unit operations and evaluate the pros and cons of introducing in situ product removal (ISPR) on a specific process

  • Design possible ways to transfer an engineered cell factory to pilot and/or full-scale

  • Design and implement a basic strategy for collection and handling of data on a fermentation process

  • Distinguish between basic AI tools for fermentation data processing.


Written examination and reports

Course requirements

Basic knowledge on the use of MATLAB at the start of the course is an advantage, but not a necessity


Lectures, problem solving, simulation exercises (Matlab/Simulink).

More information
  • Local course code
  • Study load
    ECTS 5
  • Level
  • Contact hours per week
  • Instructors
    Krist V. Gernaey, Mogens Kilstrup
  • Mode of delivery
  • Course coordinator
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